Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes.ER calcium depletion robustly activates the unfolded protein response (UPR).However, it is unclear how fluctuations in ER calcium impact organ